Lee Jong-min, Lee Jin-sung, and Choi Yeon-hui were classmates in medical school. Jong-min falls in love with Yeon-hui, but she was already in love with Jin-sung. Jong-min gives her up, falls in love with his coworker Hye-ju, and marries her. The four of them open Bo-Sung Hospital together. After seeing Jong-min comfort Yeon-hui in her troubled marriage with Jin-sung, Hye-ju suspects Yeon-hui of having her husband’s child. Hye-ju's jealousy causes a car accident which leads to the death of Jin-sung and Yeon-hui. Jong-min saves the baby's life in Yeon-hui's womb and adopts the baby as his own son. Feeling betrayed by her husband, she realizes she only has her son, Sun-woo, left by her side. But she finds out Sun-woo has a brain tumor and tries to build a medical center to save her son. Going against her wishes, Jong-min tries to build an emergency medical center. With anger suppressed and built up over 37 years, Hye-ju explodes and Jong-min faints in shock. Sun-woo returns 7 years later to find out that Cho-in is engaged to the love of his life, Seo-yeon.
Meanwhile, Cho-in leaves for China to oversee his father's operation. There, he meets a tour guide named Young-ji, a North Korean refugee, who was paid by Hye-ju to detain Cho-in without question. Young-ji begins to fall in love with Cho-in. However, Cho-in disappears on the very day she departs with him. After finding out that Cho-in was in a danger, Sun-woo, having conflicted feelings, decides to disown his brother in order to inherit the hospital as well as taking Seo-yeon for himself. Learning about his brother’s plot to have him killed, Cho-in tries to escape from China. During his escape, he loses his memory. After arriving in South Korea, under the allias of Oh Gangho, Young-ji’s cousin, Cho-in meets Young-ji again. As Cho-in gradually starts to recover his memory, he goes up against Sun-woo and Hye-ju to retrieve Bo-Sung Hospital and make his dreams come true.
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